- 专利标题: 1,5-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE AS PDE9A MODULATORS FOR THE TREATMENT OF CNS DISORDERS
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申请号: EP08855654.3申请日: 2008-11-27
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公开(公告)号: EP2217602B1公开(公告)日: 2018-08-29
- 发明人: EICKMEIER, Christian , DORNER-CIOSSEK,Cornelia , FIEGEN, Dennis , FOX, Thomas , FUCHS, Klaus , GIOVANNINI, Riccardo , HEINE, Niklas , HENDRIX, Martin , ROSENBROCK, Holger , SCHAENZLE, Gerhard
- 申请人: Boehringer Ingelheim International GmbH
- 申请人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人: Boehringer Ingelheim International GmbH
- 当前专利权人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构: Simon, Elke Anna Maria
- 优先权: EP07425764 20071130; EP08163548 20080903; EP08169282 20081117
- 国际公布: WO2009068617 20090604
- 主分类号: C07D487/04
- IPC分类号: C07D487/04 ; A61K31/519
摘要:
The invention relates to novel substituted pyrazolopyrimidines. Chemically, the compounds are characterized by general Formula (I): with R1 being phenyl or pyridyl, any of which is substituted with 1 to 4, preferably 1 to 3 substituents X; X independently of each other being selected from C2-C6-alky1 or Ci-C6-alkoxy, where C2-C6-alkyl and C1-C6-alkoxy are at least dihalogenated up to perhalogenated. preferably with 2 to 6 halogen substituents, and the halogen atoms being selected from the group of fluoro, chloro and bromo, preferably fluoro; R2 being phenyl or heteroaryl, where phenyl is substituted by 1 to 3 radicals and heteroaryl is optionally substituted by 1 to 3 radicals in each case independently of one another selected from the group of C1-C6-alkyl, C1-C6-alkoxy, hydroxycarbonyl, cyano, trifluoromethyl, amino, nitro, hydroxy, C1-C6-alkylamino, halogen, C6-C10-arylcarbonylamino, C1-C6-alkylcarbonylamino, C1-C6-alkylaminocarbonyl. C1-C6-alkoxycarbonyl, C6-C10-arylaminocarbonyl, heteroarylaminocarbonyl. heteroarylcarbonylamino, C1-C6-alkylsulphonyl-amino, C1-C6-alkylsulphonyl and C1-C6-alkylthio; The new compounds shall be used for the manufacture of medicaments, in particular medicaments for improving, perception, concentration, learning and/or memory in patients in need thereof.
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