A golf ball-forming composition, golf balls prepared from the composition and the process for preparing thereof. The golf ball-forming composition is composed of the following ingredients: polyvinyl alcohol resin 5-80 wt%, filler 0-90 wt%, natural polymer material 0-60wt%, and plasticizer 5-50 wt%. The filler is fillers conventionally used by the person skilled in the art; the natural polymer material is fibrous substance or polysaccharide based substance; and the plasticizer is substances conventionally used by the person skilled in the art. The golf ball-forming composition is water soluble and biodegradable. The water soluble and biodegradable golf ball has a hollow inside, and the surface of the ball is disposed with at least one through hole communicating with the hollow. When the golf ball is hit into water, water will enter the hollow via the through hole, thereby increasing the contact area between water and the ball and accelerating the dissolution of the ball, so that the ball may be completely biodegraded in the environment eventually.