发明公开
EP2228434A4 AMPLIFICATION METHOD FOR HEMATOPOIETIC STEM CELLS WITH HETEROCYCLIC COMPOUND
审中-公开
造血干细胞与杂环化合物扩增方法
- 专利标题: AMPLIFICATION METHOD FOR HEMATOPOIETIC STEM CELLS WITH HETEROCYCLIC COMPOUND
- 专利标题(中): 造血干细胞与杂环化合物扩增方法
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申请号: EP08857879申请日: 2008-12-05
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公开(公告)号: EP2228434A4公开(公告)日: 2013-01-23
- 发明人: NAKAMURA TAKANORI , MIYAMURA ATSUSHI , NISHINO TAITO , ISHIWATA NORIHISA , MIYAJI KATSUAKI
- 申请人: NISSAN CHEMICAL IND LTD
- 专利权人: NISSAN CHEMICAL IND LTD
- 当前专利权人: NISSAN CHEMICAL IND LTD
- 优先权: JP2007315167 2007-12-05
- 主分类号: C12N5/0789
- IPC分类号: C12N5/0789 ; A61P7/00 ; A61P7/06 ; A61P9/10 ; A61P19/08 ; A61P35/00 ; A61P35/02 ; A61P37/02
摘要:
An object of the present invention is to expand CD34 + cells ex vivo efficiently in a short term using a biologically safe and inexpensively obtainable low molecular weight compound. A still another object of the present invention is to provide an expansion agent for CD34 + cells useful for treatment of various hematopoietic disorders caused by dysfunctional hematopoietic stem cells and/or hematopoietic progenitor cells. A method for expanding CD34 + cells, which comprises culturing CD34 + cells ex vivo in the presence of a compound represented by the formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound, or a solvate thereof.
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