发明公开
EP2238147A2 17-(1'-PROPENYL)-17-3'-OXIDOESTRA-4-EN-3-ON-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL
有权
17-（1'-丙烯基）-17-3'-OXIDOESTRA -4-烯-3-酮衍生物，它们的用途及药物衍生物含
- 专利标题： 17-(1'-PROPENYL)-17-3'-OXIDOESTRA-4-EN-3-ON-DERIVAT, DESSEN VERWENDUNG UND DAS DERIVAT ENTHALTENDE ARZNEIMITTEL
- 专利标题（英）： 17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-one derivative, use thereof, and medicament containing said derivative
- 专利标题（中）： 17-（1'-丙烯基）-17-3'-OXIDOESTRA -4-烯-3-酮衍生物，它们的用途及药物衍生物含
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申请号： EP08867342.1申请日： 2008-12-23
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公开(公告)号： EP2238147A2公开(公告)日： 2010-10-13
- 发明人: KLAR, Ulrich , KUHNKE, Joachim , BOHLMANN, Rolf , HÜBNER, Jan , RING, Sven , FRENZEL, Thomas , MENGES, Frederik , BORDEN, Steffen , MUHN, Hans, Peter , PRELLE, Katja
- 申请人： Bayer Schering Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人： Bayer Schering Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 优先权： DE102007063500 20071229
- 国际公布： WO2009083268 20090709
- 主分类号： C07J21/00
- IPC分类号： C07J21/00 ; C07J41/00 ; C07J53/00 ; A61K31/58 ; A61P5/34 ; A61P5/42 ; A61P5/26
摘要：
The invention relates to 17-(1'-propenyl)-17-3'-oxidoestra-4-en-3-one derivatives with general chemical formula (1) wherein the radicals Z, R
4 , R
6a , R
6b , R
7 , R
15 , R
16a , R
16b and R
18 have the designations given in claim 1, and to the solvates, hydrates and salts thereof, including all stereoisomers of said compounds. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal complaints, and medicaments containing said derivatives, especially the application thereof in the cited cases. The derivatives according to the invention have a gestagenic effect, and in preferred cases, also an anti-mineral corticoidal and neutral to lightly androgenous effect.
4 , R
6a , R
6b , R
7 , R
15 , R
16a , R
16b and R
18 have the designations given in claim 1, and to the solvates, hydrates and salts thereof, including all stereoisomers of said compounds. The invention also relates to the use of said derivatives for producing a medicament for oral contraception and for the treatment of premenopausal, perimenopausal and postmenopausal complaints, and medicaments containing said derivatives, especially the application thereof in the cited cases. The derivatives according to the invention have a gestagenic effect, and in preferred cases, also an anti-mineral corticoidal and neutral to lightly androgenous effect.
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