发明公开
- 专利标题： NOVEL SEH INHIBITORS AND THEIR USE
- 专利标题（中）： 新型SEH抑制剂及其用途
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申请号： EP09705999.2申请日： 2009-01-30
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公开(公告)号： EP2240021A1公开(公告)日： 2010-10-20
- 发明人: MARINO, Joseph, Paul , MCATEE, John, Jeffrey
- 申请人： GlaxoSmithKline LLC
- 申请人地址： One Franklin Plaza 200 North 16th Street Philadelphia, PA 19102 US
- 专利权人： GlaxoSmithKline LLC
- 当前专利权人： GlaxoSmithKline LLC
- 当前专利权人地址： One Franklin Plaza 200 North 16th Street Philadelphia, PA 19102 US
- 代理机构： Cooke, Tracey
- 优先权： US24596 20080130
- 国际公布： WO2009097474 20090806
- 主分类号： A01N43/40
- IPC分类号： A01N43/40 ; A61K31/445 ; A61K31/16
摘要：
The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R5a, R6a, A, B, K, L, M, Y, Z, x, and m are defined herein, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
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