发明公开
EP2240516A1 METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS
有权
方式和途径改进ABZIELUNG ON CD138表达的肿瘤细胞
- 专利标题: METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS
- 专利标题(中): 方式和途径改进ABZIELUNG ON CD138表达的肿瘤细胞
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申请号: EP08865592.3申请日: 2008-12-23
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公开(公告)号: EP2240516A1公开(公告)日: 2010-10-20
- 发明人: DAELKEN, Benjamin , UHEREK, Christoph , ANDERSON, Kenneth , HIDESHIMA, Teru , BRUECHER, Christoph
- 申请人: Biotest AG , Immunogen, Inc. , Dana-Farber Cancer Institute, Inc.
- 申请人地址: Landsteinerstr. 5 63303 Dreieich DE
- 专利权人: Biotest AG,Immunogen, Inc.,Dana-Farber Cancer Institute, Inc.
- 当前专利权人: Biotest AG,Immunogen, Inc.,Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址: Landsteinerstr. 5 63303 Dreieich DE
- 代理机构: Daniels, Jeffrey Nicholas
- 优先权: US16614 20071226; US87590 20080808; US87466 20080808
- 国际公布: WO2009080832 20090702
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; C07K16/30 ; A61P35/00 ; A61K47/48 ; A61K39/395
摘要:
Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This deminished adhesion renders the tumor cells not only susceptible to the immunconjugate, but also to other agents, in particular cytotoxic agents.
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