发明授权
- 专利标题： METHODS OF PREDICTING ANTIBODY SOLUBILITY
- 专利标题（中）： 用于预测ANTIKÖRPERLÖSLICHKEIT
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申请号： EP09703185.0申请日： 2009-01-20
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公开(公告)号： EP2243031B1公开(公告)日： 2012-05-30
- 发明人: O'NEIL, Karen , JACOBS, Steven , WU, Sheng-Jiun , BETHEA, Deirdra , FENG, Yiqing
- 申请人： Janssen Biotech, Inc.
- 申请人地址： 800/850 Ridgeview Drive Horsham, PA 19044 US
- 专利权人： Janssen Biotech, Inc.
- 当前专利权人： Janssen Biotech, Inc.
- 当前专利权人地址： 800/850 Ridgeview Drive Horsham, PA 19044 US
- 代理机构： Goodfellow, Hugh Robin
- 优先权： US22385P 20080121
- 国际公布： WO2009094331 20090730
- 主分类号： G01N33/68
- IPC分类号： G01N33/68
摘要：
The invention provides methods for testing and ranking therapeutic antibody candidates for biophysical properties related to solubility and the susceptibility of the antibody to aggregate in aqueous solutions. The methods are useful for selecting among antibody libraries or variants for candidates which can be formulated at high concentrations.
公开/授权文献
- EP2243031A1 METHODS OF PREDICTING ANTIBODY SOLUBILITY 公开/授权日：2010-10-27
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