A structural integrity monitoring system (60) includes a structure (2), at least two vibration monitoring devices (20-25) mounted to the structure. Each of the at least two vibration monitoring devices (20-25) outputs a vibration response signal. The structural integrity monitoring system (60) also includes a controller (61) operatively connected to each of the at least two vibration monitoring devices (20-25). The controller (61) is configured to calculate a predicted vibration response based upon a vibration mode shape and the vibration response signal. The controller (61) then compares the predicted vibration response against a measured vibration response to detect changes in the structure (2).