发明公开
EP2244718A2 PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN 1 LOOP 2 OR 2 LOOP 1 OF AN ADRENORECEPTOR
有权
肽连接的表位A亲和抗体IN A ALPHA1-LOOP2 OR BETA2 LOOP 1所述的肾上腺能够识别
- 专利标题： PEPTIDES HAVING BINDING AFFINITY TO AN ANTIBODY WHICH RECOGNIZES AN EPITOPE ON AN 1 LOOP 2 OR 2 LOOP 1 OF AN ADRENORECEPTOR
- 专利标题（中）： 肽连接的表位A亲和抗体IN A ALPHA1-LOOP2 OR BETA2 LOOP 1所述的肾上腺能够识别
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申请号： EP09702027.5申请日： 2009-01-15
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公开(公告)号： EP2244718A2公开(公告)日： 2010-11-03
- 发明人: KUNZE, Rudolf , WALLUKAT, Gerd , ROSENTHAL, Peter , STRAUBE, Richard
- 申请人： Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch , Kunze, Rudolf
- 申请人地址： Robert-Rössle-Strasse 10 13125 Berlin-Buch DE
- 专利权人： Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch,Kunze, Rudolf
- 当前专利权人： Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch,Kunze, Rudolf
- 当前专利权人地址： Robert-Rössle-Strasse 10 13125 Berlin-Buch DE
- 代理机构： Schreiber, Christoph
- 优先权： EP08100510 20080115
- 国际公布： WO2009090227 20090723
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/08 ; A61P25/28 ; C07K14/705 ; C07K1/22
摘要：
A peptide having an ED
50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular αl loop 2 or β2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED
50 value is measured by bioassay.
50 of less than 500 nm, in particular 10 nM to an antibody which recognizes an epitope on an extracellular αl loop 2 or β2 loop1 of a human adrenoceptor wherein the antibody's binding to the epitope results in an increase of γ-secretase activity, an increased release of β-amyolid molecules and/or cellular dysfunction of cerebral blood vessel cells, glia cells or neurons, wherein the ED
50 value is measured by bioassay.
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