发明公开
- 专利标题： Novel lipid compounds
- 专利标题（中）： Neue Lipidverbindungen
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申请号： EP09159798.9申请日： 2009-05-08
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公开(公告)号： EP2248798A1公开(公告)日： 2010-11-10
- 发明人: Brændvang, Morten , Hovland, Ragnar , Holmeide, Anne, Kristin
- 申请人： Pronova BioPharma Norge AS
- 申请人地址： Vollsveien 6 P.O. Box 420 1327 Lysaker NO
- 专利权人： Pronova BioPharma Norge AS
- 当前专利权人： Pronova BioPharma Norge AS
- 当前专利权人地址： Vollsveien 6 P.O. Box 420 1327 Lysaker NO
- 代理机构： Lillegraven, Rita
- 主分类号： C07C67/31
- IPC分类号： C07C67/31 ; C07C69/708 ; C07C51/06 ; C07C51/09 ; C07C59/60 ; A61P3/06 ; A61K31/19 ; A61K31/22
摘要：
The present invention relates to lipid compounds of the general formula (I):
wherein R 1 is selected from a C 10 -C 22 alkyl, a C 10 -C 22 alkenyl having 1-6 double bonds, and a C 10 -C 22 alkynyl having 1-6 triple bonds;R 2 and R 3 are the same or different and may be selected from a group of different substituents; and X represents a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride or a carboxamide;
or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof.
The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.
wherein R 1 is selected from a C 10 -C 22 alkyl, a C 10 -C 22 alkenyl having 1-6 double bonds, and a C 10 -C 22 alkynyl having 1-6 triple bonds;R 2 and R 3 are the same or different and may be selected from a group of different substituents; and X represents a carboxylic acid or a derivative thereof, such as a carboxylic ester, a carboxylic anhydride or a carboxamide;
or a pharmaceutically acceptable salt, solvate, solvate of such salt or a prodrug thereof.
The invention also relates to pharmaceutical compositions and lipid compositions comprising such compounds, and to such compounds for use as medicaments or for use in therapy, in particular for the treatment of diseases related to the cardiovascular, metabolic and inflammatory disease area.
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