发明公开
EP2252612A1 HETEROCYCLIC COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS
有权
杂环化合物和组合物中作为c-kit和PDGFR激酶抑制剂
- 专利标题: HETEROCYCLIC COMPOUNDS AND COMPOSITIONS AS C-KIT AND PDGFR KINASE INHIBITORS
- 专利标题(中): 杂环化合物和组合物中作为c-kit和PDGFR激酶抑制剂
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申请号: EP09711557.0申请日: 2009-02-20
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公开(公告)号: EP2252612A1公开(公告)日: 2010-11-24
- 发明人: LI, Xiaolin , LIU, Xiaodong , LOREN, Jon , MOLTENI, Valentina , NABAKKA, Juliet , YEH, Vince , CHIANELLI, Donatella
- 申请人: IRM LLC
- 申请人地址: 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 专利权人: IRM LLC
- 当前专利权人: IRM LLC
- 当前专利权人地址: 131 Front Street P.O. Box HM 2899 Hamilton HM LX BM
- 代理机构: Kiddle, Simon John
- 优先权: US30912 20080222
- 国际公布: WO2009105712 20090827
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/4375 ; A61P29/00 ; A61P35/00 ; A61P37/00 ; A61P25/00 ; A61P9/00
摘要:
The invention provides a novel class of compounds of Formula I: (I) pharmaceutical compositions comprising such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFRβ kinases.
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