A medical infusion fluid handling system, such as an APD system, may be arranged to de-cap and connect one or more lines (30) (such as solution lines) with one or more spikes (160) or other connection ports on a fluid handling cassette (24). This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the lines and spikes. For example, an APD system may include a carriage (146) arranged to receive a plurality of solution lines (30) each having a connector end (31a) and a cap (31). The carriage may move along a first direction so as to move the connector ends of the solution lines along the first direction, and a cap stripper (149) may be arranged to engage with caps on the solution lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.