发明公开
EP2261215A1 Process for preparing benzazepine compounds or salts thereof
有权
Verfahrenfürdie Zubereitung von Benzazepineverbindungen oder Salzen daraus
- 专利标题： Process for preparing benzazepine compounds or salts thereof
- 专利标题（中）： Verfahrenfürdie Zubereitung von Benzazepineverbindungen oder Salzen daraus
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申请号： EP10174000.9申请日： 2006-09-01
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公开(公告)号： EP2261215A1公开(公告)日： 2010-12-15
- 发明人: Torisawa, Yasuhiro , Abe, Kaoru , Muguruma, Yasuaki , Fujita, Shigekazu , Ogawa, Hidenori , Utsumi, Naoto , Miyake, Masahiro
- 申请人： Otsuka Pharmaceutical Co., Ltd.
- 申请人地址： 9, Kandatsukasa-cho 2-chome, Chiyoda-ku Tokyo 1018535 JP
- 专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人： Otsuka Pharmaceutical Co., Ltd.
- 当前专利权人地址： 9, Kandatsukasa-cho 2-chome, Chiyoda-ku Tokyo 1018535 JP
- 代理机构： von Kreisler Selting Werner
- 优先权： JP2005254744 20050902
- 主分类号： C07D223/16
- IPC分类号： C07D223/16
摘要：
This invention provides a process for preparing benzazepine compounds of the formula (1):
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.
wherein X 1 is a halogen atom, R 1 and R 2 are a lower alkyl group, or salts thereof as well as intermediate benzoic acid compounds in high yield and high purity on industrial scale, which are useful as an intermediate for preparing a pharmaceutically active 2,3,4,5-tetrahydro-1H-1-benzazepine compound having vasopressin antagonistic activity.
公开/授权文献
- EP2261215B1 Process for preparing benzazepine compounds or salts thereof 公开/授权日：2014-12-31
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