发明公开
EP2270513A2 Methods, compositions and compound assays for inhibiting amyloid-beta protein production
审中-公开
用于抑制淀粉样β蛋白产生的方法，组合物和化合物测定
- 专利标题： Methods, compositions and compound assays for inhibiting amyloid-beta protein production
- 专利标题（中）： 用于抑制淀粉样β蛋白产生的方法，组合物和化合物测定
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申请号： EP10174529.7申请日： 2005-04-20
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公开(公告)号： EP2270513A2公开(公告)日： 2011-01-05
- 发明人: Merchiers, Pascal Gerard , Spittaels, Koenraad Frederik Florentina , Hoffmann, Marcel
- 申请人： Galapagos N.V.
- 申请人地址： Generaal de Wittelaan L11 A3 2800 Mechelen BE
- 专利权人： Galapagos N.V.
- 当前专利权人： Galapagos N.V.
- 当前专利权人地址： Generaal de Wittelaan L11 A3 2800 Mechelen BE
- 代理机构： van Kooij, Adriaan
- 优先权： US563661P 20040420
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; G01N33/566
摘要：
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide (GPR6), or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.
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