发明公开
- 专利标题： MONOCYCLIC CGRP RECEPTOR ANTAGONISTS
- 专利标题（中）： 单降钙素基因相关肽受体拮抗剂
-
申请号： EP09725978.2申请日： 2009-03-24
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公开(公告)号： EP2271346A2公开(公告)日： 2011-01-12
- 发明人: SELNICK, Harold, G. , BELL, Ian, M. , MCWHERTER, Melody , STAAS, Donnette, D. , STACHEL, Shawn, J. , STEELE, Thomas , STUMP, Craig , WOOD, Michael, R. , ZARTMAN, C., Blair
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US72236 20080328
- 国际公布： WO2009120652 20091001
- 主分类号： A61K31/54
- IPC分类号： A61K31/54 ; A61K31/44 ; C07D487/00 ; C07D211/00
摘要：
The present invention is directed to compounds of the formula (I) : (wherein variables A
1 , A
2 , A
3 , A
4 , A
5 , A
6 , A
7 , A
8 , G
1 , G
2 , G
3 , G
4 , J, Q, E
a , E
b , E
c , R
6 , R
7 , R
PG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
1 , A
2 , A
3 , A
4 , A
5 , A
6 , A
7 , A
8 , G
1 , G
2 , G
3 , G
4 , J, Q, E
a , E
b , E
c , R
6 , R
7 , R
PG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- EP2271346B1 MONOCYCLIC CGRP RECEPTOR ANTAGONISTS 公开/授权日：2014-01-01
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