发明授权
- 专利标题： ENHANCING VESSEL LESION HOMING AND REPAIR POTENTIAL OF STEM CELLS
- 专利标题（中）： 增强血管损伤修复和干细胞修复潜能
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申请号： EP09723461.1申请日： 2009-03-19
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公开(公告)号： EP2271748B1公开(公告)日： 2018-01-17
- 发明人: BARTELMEZ, Stephen, H. , GRANT, Maria
- 申请人： University of Florida Research Foundation, Inc. , Bartelmez, Stephen H.
- 申请人地址： 223 Grinter Hall Gainesville, FL 32611 US
- 专利权人： University of Florida Research Foundation, Inc.,Bartelmez, Stephen H.
- 当前专利权人： University of Florida Research Foundation, Inc.,Bartelmez, Stephen H.
- 当前专利权人地址： 223 Grinter Hall Gainesville, FL 32611 US
- 代理机构： Germinario, Claudio
- 优先权： US38164P 20080320
- 国际公布： WO2009117553 20090924
- 主分类号： C12N15/06
- IPC分类号： C12N15/06 ; A61K35/14 ; C12N5/0789 ; A61K35/28 ; A61K35/44
摘要：
Disclosed herein are methods of enhancing repair of vascular lesions involving the administration of cells in which TGF-&bgr; expression and/or activity has been transiently blocked. Other methods involve the administration of a TGF-&bgr; blocking agent to a subject who has a vascular lesion or is at risk of developing a vascular lesion. Alternatively, a TGF-&bgr; blocking agent and treated cells are co-administered to a subject in need thereof.
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