发明公开
EP2273877A1 CYCLOBUTYL SULFONES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS
有权
CYCLOBUTYL SULFONES作为NOTCH SPARING GAMMA SECRETASE抑制剂
- 专利标题： CYCLOBUTYL SULFONES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS
- 专利标题（中）： CYCLOBUTYL SULFONES作为NOTCH SPARING GAMMA SECRETASE抑制剂
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申请号： EP09734395.8申请日： 2009-04-17
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公开(公告)号： EP2273877A1公开(公告)日： 2011-01-19
- 发明人: HEIDEBRECHT, Richard, W. , LI, Chaomin , MUNOZ, Benito , ROSENAU, Andrew , SURDI, Laura, M. , TEMPEST, Paul , SILIPHAIVANH, Phieng , BRUBAKER, Jason
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US125212 20080423
- 国际公布： WO2009131906 20091029
- 主分类号： A01N41/10
- IPC分类号： A01N41/10 ; A61K31/10
摘要：
The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.
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