发明公开
EP2276731A1 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10
审中-公开
CCR10 2-磺酰基氨基-4-杂芳基butyloamide拮抗剂
- 专利标题： 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10
- 专利标题（中）： CCR10 2-磺酰基氨基-4-杂芳基butyloamide拮抗剂
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申请号： EP09730594.0申请日： 2009-04-08
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公开(公告)号： EP2276731A1公开(公告)日： 2011-01-26
- 发明人: ABEYWARDANE, Asitha , COGAN, Derek , CHOI, Younggi , GAO, Donghong A. , GOLDBERG, Daniel R. , HEIM-RIETHER, Alexander , MILLER, Craig Andrew , RAMSDEN, Philip Dean , SMITH KEENAN, Lana Louise , SNOW, Roger John , YU, Yang
- 申请人： Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co. KG
- 申请人地址： Binger Strasse 173 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim DE
- 代理机构： Hammann, Heinz
- 优先权： US43416P 20080409
- 国际公布： WO2009126675 20091015
- 主分类号： C07D207/34
- IPC分类号： C07D207/34 ; C07D211/16 ; C07D403/12 ; C07D513/04 ; A61K31/439 ; A61P25/28
摘要：
This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R
1 , R
2 , R
4 . Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
1 , R
2 , R
4 . Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.
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