发明公开
- 专利标题： COMPOUNDS FOR USE IN THERAPY
- 专利标题（中）： VERBINDUNGENFÜRTHERAPEUTISCHE ZWECKE
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申请号： EP09735284.3申请日： 2009-04-22
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公开(公告)号： EP2278995A2公开(公告)日： 2011-02-02
- 发明人: BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc
- 申请人： Bangor University , Universiteit Gent
- 申请人地址： Bangor Gwynedd LL57 2UW GB
- 专利权人： Bangor University,Universiteit Gent
- 当前专利权人： Bangor University,Universiteit Gent
- 当前专利权人地址： Bangor Gwynedd LL57 2UW GB
- 代理机构： Delaney, Jennifer
- 优先权： GB0807305 20080422
- 国际公布： WO2009130506 20091029
- 主分类号： A61K39/04
- IPC分类号： A61K39/04 ; A61K39/39
摘要：
A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R
1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R
2 , R
3 and R
4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR
5 ; wherein R
5 is alkyl or haloalkyl, and A is O, S or NR
6 , wherein R
6 may be H or 20 alkyl.
1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R
2 , R
3 and R
4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR
5 ; wherein R
5 is alkyl or haloalkyl, and A is O, S or NR
6 , wherein R
6 may be H or 20 alkyl.
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