发明授权
EP2280024B1 POLYPEPTIDE SPECIFICALLY BINDING TO PHOSPHATIDYLSERINE AND USE THEREOF
有权
与特异性结合其使用磷脂酰丝氨酸多肽
- 专利标题： POLYPEPTIDE SPECIFICALLY BINDING TO PHOSPHATIDYLSERINE AND USE THEREOF
- 专利标题（中）： 与特异性结合其使用磷脂酰丝氨酸多肽
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申请号： EP09714117.0申请日： 2009-02-25
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公开(公告)号： EP2280024B1公开(公告)日： 2014-12-17
- 发明人: KIM, In San , LEE, Byung Heon , NARENDRA, Thapa
- 申请人： Kyungpook National University Industry- Academic Cooperation Foundation
- 申请人地址： Kyungpook National University 1370 Sangyeok-dong Buk-gu Daegu 702-701 KR
- 专利权人： Kyungpook National University Industry- Academic Cooperation Foundation
- 当前专利权人： Kyungpook National University Industry- Academic Cooperation Foundation
- 当前专利权人地址： Kyungpook National University 1370 Sangyeok-dong Buk-gu Daegu 702-701 KR
- 代理机构： Stolmár & Partner
- 优先权： KR20080016944 20080225
- 国际公布： WO2009107971 20090903
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; G01N33/574 ; G01N33/92 ; A61K47/48 ; A61K49/00
摘要：
The present invention relates to a polypeptide specifically bound to phosphatidylserine and use thereof, and more particularly to a polypeptide having an amino acid sequence designated as sequence number 1 and specifically bound to phosphatidylserine, a phosphatidylserine detecting composition containing the polypeptide as an active ingredient, a detecting method of phosphatidylserine by using polypeptide, a apoptotic cell detecting containing the polypeptide as an active ingredient, a drug delivery composition containing the polypeptide as an active ingredient, a composition for treatment and prevention of a tumorous disease, and a composition for visualization of a tumorous region. A polypeptide having an amino acid sequence designated sequence number 1 is specifically bound to phosphatidylserine. Therefore, the polypeptide of the present invention is useful for detecting phosphatidylserine, furthermore detecting apoptotic cells expressing phosphatidylserine on the surface of the cell and tumor cells, and also useful for visualization of apoptotic cells or tumor cells.
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