发明公开
EP2283016A1 THIOPHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE
有权
噻吩基取代的2-亚氨基-3-甲基吡咯并嘧啶酮化合物作为BACE-1抑制剂，组合物及其应用
- 专利标题： THIOPHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE
- 专利标题（中）： 噻吩基取代的2-亚氨基-3-甲基吡咯并嘧啶酮化合物作为BACE-1抑制剂，组合物及其应用
-
申请号： EP09734309.9申请日： 2009-04-21
-
公开(公告)号： EP2283016A1公开(公告)日： 2011-02-16
- 发明人: STAMFORD, Andrew, W. , ZHU, Zhaoning , MANDAL, Mihirbaran , LIU, Xiaoxiang
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US47006 20080422
- 国际公布： WO2009131974 20091029
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61P25/28 ; A61K31/519
摘要：
In its many embodiments, the present invention provides provides certain thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds (or tautomers or a pharmaceutically acceptable salts thereof) having the structural Formula (III): wherein R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , and R
9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , and R
9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
公开/授权文献
信息查询
