发明公开
EP2288613A1 PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE
有权
苯基-2-亚氨基-3- METHYLPYRROLOPYRIMIDINONVERBINDUNGEN AS BACE-1抑制剂，组合物和它们的使用
- 专利标题： PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE
- 专利标题（中）： 苯基-2-亚氨基-3- METHYLPYRROLOPYRIMIDINONVERBINDUNGEN AS BACE-1抑制剂，组合物和它们的使用
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申请号： EP09734237.2申请日： 2009-04-21
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公开(公告)号： EP2288613A1公开(公告)日： 2011-03-02
- 发明人: STAMFORD, Andrew, W. , ZHU, Zhaoning , MANDAL, Mihirbaran , WU, Yusheng , CUMMING, Jared, N. , LIU, Xiaoxiang , LI, Guoqing , ISERLOH, Ulrich
- 申请人： Schering Corporation
- 申请人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033 US
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, NJ 07033 US
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US47006 20080422
- 国际公布： WO2009131975 20091029
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61P25/28 ; A61K31/519
摘要：
In its many embodiments, the present invention provides provides certain 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , and R
9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , and R
9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
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