发明公开
EP2289525A1 Use of IL-21 for expanding lymphoid cells and for anticancer adoptive immunotherapy
审中-公开
使用IL-21的用于传播Lymhoidzellen，以及针对癌症的过继免疫治疗
- 专利标题： Use of IL-21 for expanding lymphoid cells and for anticancer adoptive immunotherapy
- 专利标题（中）： 使用IL-21的用于传播Lymhoidzellen，以及针对癌症的过继免疫治疗
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申请号： EP10171625.6申请日： 2003-06-06
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公开(公告)号： EP2289525A1公开(公告)日： 2011-03-02
- 发明人: Nelson, Andrew J. , Hughes, Steven D. , Holly, Richard D. , Kindsvogel, Wayne, R.
- 申请人： ZymoGenetics, Inc.
- 申请人地址： 1201 Eastlake Avenue East Seattle, WA 98102 US
- 专利权人： ZymoGenetics, Inc.
- 当前专利权人： ZymoGenetics, Inc.
- 当前专利权人地址： 1201 Eastlake Avenue East Seattle, WA 98102 US
- 代理机构： Griffin, Philippa Jane
- 优先权： US387127P 20020607
- 主分类号： A61K35/14
- IPC分类号： A61K35/14 ; A61K35/28 ; C12N5/00 ; A61P35/00
摘要：
There is provided an in vitro method for expansion of hematopoietic cells and hematopoietic cell progenitors comprising: culturing bone marrow or peripheral blood cells with a composition comprising an amount of IL-21 sufficient to produce an increase in the number of lymphoid cells in the bone marrow or peripheral blood cells as compared to bone marrow or peripheral blood cells cultured in the absence of IL-21. There are also provided anti-cancer effector cells for use in the treatment of cancer in a patient by adoptive immunotherapy, wherein said anti-cancer effector cells have been obtained from the patient, and wherein the use comprises an initial ex vivo step of expanding the anti-cancer effector cells in culture in the presence of IL-21.
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