发明公开
EP2291659A2 CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
有权
小CHIMERA分子招募抗体,癌细胞
- 专利标题: CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS
- 专利标题(中): 小CHIMERA分子招募抗体,癌细胞
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申请号: EP09746950.6申请日: 2009-05-13
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公开(公告)号: EP2291659A2公开(公告)日: 2011-03-09
- 发明人: SPIEGEL, David , MURELLI, Ryan , ZHANG, Andrew
- 申请人: Yale University, Inc.
- 申请人地址: 2 Whitney Avenue New Haven CT 06511 US
- 专利权人: Yale University, Inc.
- 当前专利权人: Yale University, Inc.
- 当前专利权人地址: 2 Whitney Avenue New Haven CT 06511 US
- 代理机构: Dall'Olio, Giancarlo
- 优先权: US127539P 20080513
- 国际公布: WO2009139863 20091119
- 主分类号: G01N33/574
- IPC分类号: G01N33/574
摘要:
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
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