A peritoneal dialysis machine (100) comprising: a housing including at least one pump actuator, a rotational to linear motion converter operable with a shaft leading to a pump head, at least one valve actuator and an assembly forming a wall of the housing for interfacing with a disposable cassette, the assembly including: a plate (30) that faces a flexible sheet of the cassette when loaded into the machine; at least one pump aperture defined by the plate; the at least one pump head moveable out of and retractable into the at least one pump aperture translated via the rotational to linear motion converter to operate a corresponding pumping portion of the flexible sheet of the cassette; at least one valve aperture defined by the plate; at least one valve apparatus moveable out of and retractable into the at least one valve aperture to operate a valve portion of the flexible sheet of the cassette; at least one sensor aperture defined by the plate; and at least one sensor (74) located in the at least one sensor aperture, the at least one sensor operable with a sensor portion of the flexible sheet of the cassette.