- 专利标题： Monoclonal antibodies against claudin-18 for treatment of cancer
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申请号： EP10011773.8申请日： 2006-11-24
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公开(公告)号： EP2311877A2公开(公告)日： 2011-04-20
- 发明人: Sahin, Ugur , Türeci, Özlem , Usener, Dirk , Fritz, Stefan , Uherek, Christoph , Brandenburg, Gunda , Geppert, Harald-Gerhard , Schröder, Anja Kristina , Thiel, Philippe
- 申请人： Ganymed Pharmaceuticals AG , Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
- 申请人地址： Freiligrathstrasse 12 55131 Mainz DE
- 专利权人： Ganymed Pharmaceuticals AG,Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
- 当前专利权人： Ganymed Pharmaceuticals AG,Johannes Gutenberg-Universität Mainz, vertreten durch den Präsidenten
- 当前专利权人地址： Freiligrathstrasse 12 55131 Mainz DE
- 代理机构： Schnappauf, Georg
- 优先权： EP05025657 20051124
- 主分类号： C07K16/30
- IPC分类号： C07K16/30 ; A61K39/395 ; A61P35/00 ; C12N5/12 ; A61K47/48
摘要：
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
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