发明公开
EP2314693A3 Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
审中-公开
由核苷与网站相关的变化所造成的CpG寡核苷酸的免疫刺激调制
- 专利标题: Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
- 专利标题(中): 由核苷与网站相关的变化所造成的CpG寡核苷酸的免疫刺激调制
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申请号: EP10010051.0申请日: 2000-08-14
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公开(公告)号: EP2314693A3公开(公告)日: 2012-11-28
- 发明人: Agrawal, Sudhir
- 申请人: Idera Pharmaceuticals, Inc.
- 申请人地址: 345 Vassar Street Cambridge, MA 02139 US
- 专利权人: Idera Pharmaceuticals, Inc.
- 当前专利权人: Idera Pharmaceuticals, Inc.
- 当前专利权人地址: 345 Vassar Street Cambridge, MA 02139 US
- 代理机构: Müller, Christian Stefan Gerd
- 优先权: US148798P 19990813
- 主分类号: C12N15/117
- IPC分类号: C12N15/117 ; A61K31/7125 ; C07H21/00
摘要:
The invention provides methods for modulating the immune response caused by CpG-containing oligonucleotides. The methods according to the invention enable decreasing the immunostimulatory effect for antisense applications.
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