发明授权
EP2315755B1 SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
有权
二氢噻的合成[3,2-D] PYRIMIDINDIOLEN及类似PYRIMIDINDIOLEN
- 专利标题： SYNTHESIS OF DIHYDROTHIENO[3,2-d]PYRIMIDINE DIOLS AND SIMILAR PYRIMIDINE DIOLS
- 专利标题（中）： 二氢噻的合成[3,2-D] PYRIMIDINDIOLEN及类似PYRIMIDINDIOLEN
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申请号： EP09736709.8申请日： 2009-05-07
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公开(公告)号： EP2315755B1公开(公告)日： 2012-08-08
- 发明人: FRUTOS, Rogelio, Perez , TAMPONE, Thomas, G. , MULDER, Jason, Alan , KRISHNAMURTHY, Dhileepkumar , SENANAYAKE, Chris, Hugh
- 申请人： Boehringer Ingelheim International GmbH , Boehringer Ingelheim Pharma GmbH & Co. KG
- 申请人地址： Binger Strasse 173 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人： Boehringer Ingelheim International GmbH,Boehringer Ingelheim Pharma GmbH & Co. KG
- 当前专利权人地址： Binger Strasse 173 55216 Ingelheim DE
- 代理机构： Hammann, Heinz
- 优先权： US52816P 20080513
- 国际公布： WO2009140127 20091119
- 主分类号： C07D239/70
- IPC分类号： C07D239/70 ; C07D495/04
摘要：
The present invention relates to an improved process for the preparation of dihydrothieno[3,2-
d ]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
d ]pyrimidine diols, and similar pyrimidine diols, that is efficient, high-yielding, and does not require expensive and potentially unstable intermediates. The diols are used as intermediates in the synthesis of pyrimidine compounds which inhibit PDE4, and are thus useful in the treatment of respiratory or gastrointestinal diseases and complaints, peripheral or central nervous system diseases and disorders, inflammatory conditions, and cancers.
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