发明公开
EP2318391A1 TRICYCLIC HETEROCYCLE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS
审中-公开
三环HETEROFLEXIBLE CYCLE衍生物作为组胺H3拮抗剂
- 专利标题: TRICYCLIC HETEROCYCLE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS
- 专利标题(中): 三环HETEROFLEXIBLE CYCLE衍生物作为组胺H3拮抗剂
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申请号: EP09790675.4申请日: 2009-07-21
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公开(公告)号: EP2318391A1公开(公告)日: 2011-05-11
- 发明人: DE LERA RUIZ, Manuel , BERLIN, Michael, Y. , ZHENG, Junying , ASLANIAN, Robert, G. , MCCORMICK, Kevin, D. , ZENG, Qingbei
- 申请人: Schering Corporation
- 申请人地址: 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 专利权人: Schering Corporation
- 当前专利权人: Schering Corporation
- 当前专利权人地址: 2000 Galloping Hill Road Kenilworth, NJ 07033-0530 US
- 代理机构: Buchan, Gavin MacNicol
- 优先权: US82966P 20080723
- 国际公布: WO2010011653 20100128
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D413/14 ; C07D417/12 ; C07D417/14 ; C07D495/14 ; A61P11/02 ; A61K31/445 ; A61P37/08
摘要:
The present invention relates to novel Tricyclic Heterocylce Derivatives, pharmaceutical compositions comprising the Tricyclic Heterocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. R1 is formula (Ia), (Ib) or (Ic); R
2 is alkvl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl. any of which can be optionally substituted with R
11 ; M
1 is -CH-. -C(halo)- or -N-; Y is -C(O)-, -S-. -S(O)-, -S(O)
2 -, -CH
2 - or -O-, such that Y is not -O- when an adjacent atom is N.
2 is alkvl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl. any of which can be optionally substituted with R
11 ; M
1 is -CH-. -C(halo)- or -N-; Y is -C(O)-, -S-. -S(O)-, -S(O)
2 -, -CH
2 - or -O-, such that Y is not -O- when an adjacent atom is N.
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