发明公开
EP2318391A1 TRICYCLIC HETEROCYCLE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS 审中-公开
三环HETEROFLEXIBLE CYCLE衍生物作为组胺H3拮抗剂

TRICYCLIC HETEROCYCLE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS
摘要:
The present invention relates to novel Tricyclic Heterocylce Derivatives, pharmaceutical compositions comprising the Tricyclic Heterocycle Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. R1 is formula (Ia), (Ib) or (Ic); R
2 is alkvl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl. any of which can be optionally substituted with R
11 ; M
1 is -CH-. -C(halo)- or -N-; Y is -C(O)-, -S-. -S(O)-, -S(O)
2 -, -CH
2 - or -O-, such that Y is not -O- when an adjacent atom is N.
信息查询
0/0