发明公开
- 专利标题： AURORA KINASE MODULATORS AND METHODS OF USE
- 专利标题（中）： 极光激酶和调节剂的应用方法
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申请号： EP09740559.1申请日： 2009-08-04
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公开(公告)号： EP2321298A2公开(公告)日： 2011-05-18
- 发明人: DEAK, Holly L. , GEUNS-MEYER, Stephanie D. , HUMAN, Jason B. , MARTIN, Mathew , MARX, Isaac
- 申请人： Amgen Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 93012 US
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 93012 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US86107P 20080804
- 国际公布： WO2010017240 20100211
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; C07D403/12 ; C07D403/14 ; A61K31/506 ; A61P35/00
摘要：
The present invention relates to chemical compounds having a general formula I (I) wherein A
1-6 , L
1 , R
1 , R
4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinase proteins. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.
1-6 , L
1 , R
1 , R
4-6 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinase proteins. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds and methods of treating disease states related to the activity of Aurora kinase.
公开/授权文献
- EP2321298B1 AURORA KINASE MODULATORS AND METHODS OF USE 公开/授权日：2013-10-02
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