发明公开
EP2321317A1 FUSED PYRROLIDINO-CYCLOPROPANE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS
有权
共11-β-羟基类固醇脱氢酶1融合PYRROLIDINOCYCLOPROPAN衍生物作为选择性抑制剂，
- 专利标题： FUSED PYRROLIDINO-CYCLOPROPANE DERIVATIVES AS SELECTIVE 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS
- 专利标题（中）： 共11-β-羟基类固醇脱氢酶1融合PYRROLIDINOCYCLOPROPAN衍生物作为选择性抑制剂，
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申请号： EP09777657.9申请日： 2009-08-05
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公开(公告)号： EP2321317A1公开(公告)日： 2011-05-18
- 发明人: VALEUR, Eric , LEPIFRE, Franck , ROCHE, Didier , CARNIATO, Denis , CHRISTMANN-FRANCK, Serge , SCHMIDLIN, Fabien
- 申请人： Merck Patent GmbH
- 申请人地址： Frankfurter Strasse 250 64293 Darmstadt DE
- 专利权人： Merck Patent GmbH
- 当前专利权人： Merck Patent GmbH
- 当前专利权人地址： Frankfurter Strasse 250 64293 Darmstadt DE
- 优先权： EP08290822 20080901
- 国际公布： WO2010022850 20100304
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/407 ; A61P3/10
摘要：
The present invention relates to fused pyrrolidino-cyclopropane derivatives according to Formulae (I) to (II), as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1 ) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis/ cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
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