发明授权
EP2326623B1 BETA-AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS
有权
β-和γ-氨基 - 异喹啉酰胺化合物和取代的苯甲酰胺化合物
- 专利标题： BETA-AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS
- 专利标题（中）： β-和γ-氨基 - 异喹啉酰胺化合物和取代的苯甲酰胺化合物
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申请号： EP09790775.2申请日： 2009-07-23
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公开(公告)号： EP2326623B1公开(公告)日： 2014-04-16
- 发明人: DELONG, Mitchell, A. , STURDIVANT, Jill, Marie , ROYALTY, Susan, M.
- 申请人： Aerie Pharmaceuticals, Inc.
- 申请人地址： 7020 Kit Creek Road, Suite 270 P. O. box 12320 Research Triangle Park, NC 27709 US
- 专利权人： Aerie Pharmaceuticals, Inc.
- 当前专利权人： Aerie Pharmaceuticals, Inc.
- 当前专利权人地址： 7020 Kit Creek Road, Suite 270 P. O. box 12320 Research Triangle Park, NC 27709 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： US180259 20080725
- 国际公布： WO2010011853 20100128
- 主分类号： C07D217/02
- IPC分类号： C07D217/02 ; C07D217/24 ; C07D333/24 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D413/12 ; C07D417/12 ; A61K31/472 ; A61P27/06
摘要：
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents. The compounds of the invention are useful in the treatment of a variety of diseases and conditions including eye diseases such as glaucoma, cardiovascular diseases, and diseases characterized by abnormal growth, such as cancers. The invention further provides compositions containing the beta or gamma-amino isoquinoline amide compounds or substituted benzamide compounds.
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