发明公开
- 专利标题： Mitotic kinesin inhibitor
- 专利标题（中）： M档，驱动蛋白抑制剂
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申请号： EP11158215.1申请日： 2004-04-16
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公开(公告)号： EP2327702A1公开(公告)日： 2011-06-01
- 发明人: Murakata, Chikara , Yamashita, Yoshinori , NAKAI, Ryuichiro , Akasaka, Kazuhito , Ino, Yoji , Kato, Kazuhiko , Kitamura, Yushi
- 申请人： Kyowa Hakko Kirin Co., Ltd. , FUJIFILM Corporation
- 申请人地址： 1-6-1, Ohtemachi, Chiyoda-ku Tokyo JP
- 专利权人： Kyowa Hakko Kirin Co., Ltd.,FUJIFILM Corporation
- 当前专利权人： Kyowa Hakko Kirin Co., Ltd.,FUJIFILM Corporation
- 当前专利权人地址： 1-6-1, Ohtemachi, Chiyoda-ku Tokyo JP
- 代理机构： Polypatent
- 优先权： JP2003114071 20030418; JP2003164727 20030610
- 主分类号： C07D285/12
- IPC分类号： C07D285/12 ; C07D417/04 ; C07D417/12 ; A61K31/433 ; A61K31/4439 ; A61K31/5377 ; A61K31/506 ; A61P9/04 ; A61P9/10 ; A61P19/02 ; A61P37/02
摘要：
A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient:
[wherein R 1 represents a hydrogen atom and the like, R 2 represents a hydrogen atom, -C(=W)R 6 (wherein W represents an oxygen atom or a sulfur atom, and R 6 represents substituted or unsubstituted lower alkyl and the like) and the like, R 3 represents -C(=Z)R 19 (wherein Z represents an oxygen atom or a sulfur atom, and R 19 represents substituted or unsubstituted lower alkyl and the like) and the like, R 4 represents substituted or unsubstituted lower alkyl and the like, and R 5 represents substituted or unsubstituted aryl and the like] and the like are provided.
[wherein R 1 represents a hydrogen atom and the like, R 2 represents a hydrogen atom, -C(=W)R 6 (wherein W represents an oxygen atom or a sulfur atom, and R 6 represents substituted or unsubstituted lower alkyl and the like) and the like, R 3 represents -C(=Z)R 19 (wherein Z represents an oxygen atom or a sulfur atom, and R 19 represents substituted or unsubstituted lower alkyl and the like) and the like, R 4 represents substituted or unsubstituted lower alkyl and the like, and R 5 represents substituted or unsubstituted aryl and the like] and the like are provided.
公开/授权文献
- EP2327702B1 Mitotic kinesin inhibitor 公开/授权日：2012-08-29
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