发明公开
EP2331522A2 TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF
有权
四氢吡啶和DIHYDROPYRROLYLVERBINDUNGEN及其用途
- 专利标题： TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF
- 专利标题（中）： 四氢吡啶和DIHYDROPYRROLYLVERBINDUNGEN及其用途
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申请号： EP09802045.6申请日： 2009-08-03
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公开(公告)号： EP2331522A2公开(公告)日： 2011-06-15
- 发明人: MIKAMIYAMA, Hidenori , NI, Chiyou , SHAO, Bin , TAFESSE, Laykea
- 申请人： Purdue Pharma LP , Shionogi Co., Ltd.
- 申请人地址： One Stamford Forum 201 Tresser Boulevard Stamford, CT 06901-3431 US
- 专利权人： Purdue Pharma LP,Shionogi Co., Ltd.
- 当前专利权人： Purdue Pharma LP,Shionogi Co., Ltd.
- 当前专利权人地址： One Stamford Forum 201 Tresser Boulevard Stamford, CT 06901-3431 US
- 代理机构： Vos, Derk
- 优先权： US129956P 20080801
- 国际公布： WO2010014257 20100204
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D413/14 ; C07D409/14 ; C07D401/14 ; C07D413/04 ; C07D451/02 ; A61K31/44 ; A61P25/28 ; A61P25/04
摘要：
The invention relates to tetrahydropyridinyl and dihydropyrrolyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X, Y, Z, R
1 , R
2 , m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
1 , R
2 , m, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
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