发明公开
- 专利标题： THE STABILISATION OF PROTEINS
- 专利标题（中）： 镇定蛋白的
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申请号： EP09785343.6申请日： 2009-07-16
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公开(公告)号： EP2341940A1公开(公告)日： 2011-07-13
- 发明人: JEZEK, Jan , POTTER, Charles
- 申请人： Arecor Limited
- 申请人地址： 2 Cambridge Science Park Cambridge CB4 OFE GB
- 专利权人： Arecor Limited
- 当前专利权人： Arecor Limited
- 当前专利权人地址： 2 Cambridge Science Park Cambridge CB4 OFE GB
- 代理机构： Goodall, Scott
- 优先权： GB0813006 20080716
- 国际公布： WO2010094906 20100826
- 主分类号： A61K47/12
- IPC分类号： A61K47/12 ; A61K38/27 ; A61K38/28 ; A61K38/22 ; A61K47/18 ; A61K39/29 ; A61K38/26 ; A61K9/14 ; C07K14/00 ; C07K14/52 ; C07K14/475 ; C07K14/575 ; C07K16/00
摘要：
A dry composition for use in therapy or diagnosis, obtainable by drying an aqueous composition comprising a protein and one or more displacement buffers, such as TRIS, lactate, lysine and histidine wherein the pH of the aqueous composition is such that the protein is stable, wherein the or each displacement buffer has a pKa that is at least 1 unit greater or less than the pH of the aqueous composition, and wherein the aqueous composition is substantially free of a conventional buffer having a pKa that is within one pH unit of the pH of the aqueous composition.
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