发明公开
EP2344475A1 QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS
有权
喹唑啉酮，喹诺酮类和相关类似物AS SIRTUINMODULATOREN
- 专利标题： QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS
- 专利标题（中）： 喹唑啉酮，喹诺酮类和相关类似物AS SIRTUINMODULATOREN
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申请号： EP09817056.6申请日： 2009-09-29
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公开(公告)号： EP2344475A1公开(公告)日： 2011-07-20
- 发明人: VU, Chi, B. , OALMANN, Christopher , PERNI, Robert, B. , WHITE, Brian
- 申请人： Sirtris Pharmaceuticals, Inc.
- 申请人地址： 200 Technology Square, Suite 300 Cambridge, MA 02139 US
- 专利权人： Sirtris Pharmaceuticals, Inc.
- 当前专利权人： Sirtris Pharmaceuticals, Inc.
- 当前专利权人地址： 200 Technology Square, Suite 300 Cambridge, MA 02139 US
- 代理机构： McNab, Donald C.
- 优先权： US194576P 20080929
- 国际公布： WO2010037129 20100401
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/5377 ; C07D405/12 ; A61K31/4375 ; A61P3/10 ; C07D413/12 ; A61K31/439 ; A61P5/50 ; C07D417/12 ; A61K31/4709 ; C07D239/91 ; C07D417/14 ; A61K31/497 ; C07D401/14 ; C07D453/02 ; A61K31/506 ; C07D403/12 ; A61K31/517 ; C07D403/14
摘要：
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
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