发明公开
EP2356995A3 Process of preparation of formulations of the peptide Angiotensin-(1-7) and its analogues, agonists and antagonists using cyclodextrins, liposomes and biodegradable polymers and/or mixtures and products thereof
审中-公开
一种用于肽血管紧张素 - （1-7）和其类似物，环糊精使用激动剂和拮抗剂，脂质体和可生物降解的聚合物和/或它们的混合物及其产品的制剂的制备过程
- 专利标题： Process of preparation of formulations of the peptide Angiotensin-(1-7) and its analogues, agonists and antagonists using cyclodextrins, liposomes and biodegradable polymers and/or mixtures and products thereof
- 专利标题（中）： 一种用于肽血管紧张素 - （1-7）和其类似物，环糊精使用激动剂和拮抗剂，脂质体和可生物降解的聚合物和/或它们的混合物及其产品的制剂的制备过程
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申请号： EP11160834.5申请日： 2002-11-05
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公开(公告)号： EP2356995A3公开(公告)日： 2011-08-24
- 发明人: Santos, Robson Augusto Souza , Nadu, Ana Paula , Frezard, Frederic Jean Georges , Sinisterra, Rubén Dario
- 申请人： Universidade Federal de Minas Gerais-UFMG
- 申请人地址： Avenida Antonio Carlos, 6627, 7o. andar-CTIT, Pampulha CEP-31270-901 Belo Horizonte, MG BR
- 专利权人： Universidade Federal de Minas Gerais-UFMG
- 当前专利权人： Universidade Federal de Minas Gerais-UFMG
- 当前专利权人地址： Avenida Antonio Carlos, 6627, 7o. andar-CTIT, Pampulha CEP-31270-901 Belo Horizonte, MG BR
- 代理机构： Kaiser, Jürgen
- 优先权： BR01055097 20011105
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; A61P9/00 ; A61K9/127 ; A61K9/16 ; A61K47/40 ; A61P17/02 ; A61P13/00 ; A61P15/00 ; A61P3/10 ; A61P35/00
摘要：
There is no description in the state of technique of a formulation, application or product of D-Ala 7 -Angiotensin-(1-7) (A-779) and analogues and derivatives, D-Pro 7 -Angiotensin-(1-7) and analogues or derivatives or of Ang-(1-7) analogues or derivatives using cyclodextrines, liposomes, biodegradable polymers and its derivatives for the study or treatment of arterial hypertension and other cardiovascular diseases and its complications, wounds, burns, erithema, tumors, diabetes mellitus, sperm mobility, nephropathy, gastrointestinal and gynaecological disorders, angiogenesis, angioplatsy, alopecia and blood diseases in animals of warm blood, or as ligands for de G-protein-coupled receptor MAS. This characterizes the present invention as a more effective option for the study and treatment of pathologies associated or not to this receptor. The present invention is characterized by the combination of two different technologies: the molecular encapsulation of the peptide Angiotensin-(1-7) and its analogues and derivates in cyclodextrin and the microencapsulation in biodegradable polymers and liposomes. It is also characterized by the increase of this peptide and its analogues and derivatives using the formulation of the present invention.
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