发明公开
- 专利标题: FGF21 MUTANTS AND USES THEREOF
- 专利标题(中): FGF21-MUTANTEN UND IHRE VERWENDUNGEN
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申请号: EP09748878.7申请日: 2009-10-08
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公开(公告)号: EP2358749A2公开(公告)日: 2011-08-24
- 发明人: WALKER, Kenneth W. , GEGG, Colin, V., Jr. , HECHT, Randy I. , BELOUSKI, Edward J. , LI, Yue-Sheng , MICHAELS, Mark L. , XU, Jing , ELLISON, Murielle M.
- 申请人: Amgen, Inc
- 申请人地址: One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 专利权人: Amgen, Inc
- 当前专利权人: Amgen, Inc
- 当前专利权人地址: One Amgen Center Drive Thousand Oaks, California 91320-1799 US
- 代理机构: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权: US195761P 20081010
- 国际公布: WO2010042747 20100415
- 主分类号: C07K14/50
- IPC分类号: C07K14/50 ; A61K38/18
摘要:
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides comprising extended in vivos half-lives, pharmaceutical compositions comprising FGF21 mutant polypeptides having extended in vivos half lives, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
公开/授权文献
- EP2358749B1 FGF21 MUTANTS AND USES THEREOF 公开/授权日:2018-07-18
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