An improved differential coat weight technique employs a novel algorithm for measuring the weight of a coating material that has been deposited onto a sheet of substrate. The invention employs dual x-ray or nuclear gauges such that, even though the downstream sensor is never exposed to uncoated sheet substrate, imparting the downstream sensor with the ability to predict results that it would have yielded when measuring the uncoated sheet substrate, leads to the development of a coat weight calibration protocol from which the basis weight of the coating can be ascertained directly from measurements from the upstream and downstream sensors. No subtraction of results is required. Moreover, the two sensors do not need to be re-calibrated whenever the relative proportions of the coating and base substrate change. The technique is particularly suited for applications where the coating material and substrate are made of substances that have very different atomic numbers.