发明公开
EP2363399A1 Labelled analogues of halobenzamides as radiopharmaceuticals
审中-公开
Markierte Halobenzamid - Analoga als Radiopharmazeutika
- 专利标题： Labelled analogues of halobenzamides as radiopharmaceuticals
- 专利标题（中）： Markierte Halobenzamid - Analoga als Radiopharmazeutika
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申请号： EP11167370.3申请日： 2007-07-27
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公开(公告)号： EP2363399A1公开(公告)日： 2011-09-07
- 发明人: Madelmont, Jean-Claude , Chezal, Jean-Michel , Chavignon, Olivier , Teulade, Jean-Claude , Moins, Nicole
- 申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université d'Auvergne
- 申请人地址： 101, rue de Tolbiac 75013 Paris FR
- 专利权人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),Université d'Auvergne
- 当前专利权人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),Université d'Auvergne
- 当前专利权人地址： 101, rue de Tolbiac 75013 Paris FR
- 代理机构： Le Coupanec, Pascale A.M.P.
- 优先权： FR0653138 20060727
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D219/06 ; A61K31/165 ; C07D209/42 ; C07D215/54 ; C07D217/26 ; C07D235/24 ; C07D237/26 ; C07D333/68 ; C07C233/62
摘要：
The present invention relates to the use of a compound of formula (I):
in which
R 1 represents a radionuclide,
Ar represents an aromatic nucleus,
m is an integer varying from 2 to 4,
R 2 and R 3 represent, independently of one another, a hydrogen atom, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.
in which
R 1 represents a radionuclide,
Ar represents an aromatic nucleus,
m is an integer varying from 2 to 4,
R 2 and R 3 represent, independently of one another, a hydrogen atom, a (C 1 -C 6 )alkyl group, a (C 1 -C 6 )alkenyl group or an aryl group chosen from a phenyl, benzyl, imidazolyl, pyridyl, pyrimidinyl, pyrazinyl, indolyl, indazolyl, furyl and thienyl group, and their addition salts with pharmaceutically acceptable acids, in the preparation of a radiopharmaceutical composition intended for the diagnosis and/or treatment of melanoma.
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