发明公开
EP2364156A2 MODIFIED PROTOZOAN EXPRESSING AT LEAST TWO VARIABLE SURFACE PROTEINS (VSP), A VACCINE COMPRISING IT AND PROCEDURES, USES, AND METHODS THEREOF
有权
改性原生动物，所述至少两个可变表面蛋白（VSP的）表示ON该含疫苗和方法，应用和方法THEREFOR
- 专利标题： MODIFIED PROTOZOAN EXPRESSING AT LEAST TWO VARIABLE SURFACE PROTEINS (VSP), A VACCINE COMPRISING IT AND PROCEDURES, USES, AND METHODS THEREOF
- 专利标题（中）： 改性原生动物，所述至少两个可变表面蛋白（VSP的）表示ON该含疫苗和方法，应用和方法THEREFOR
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申请号： EP09799724.1申请日： 2009-12-02
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公开(公告)号： EP2364156A2公开(公告)日： 2011-09-14
- 发明人: LUJAN, Hugo Daniel
- 申请人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet) , Universidad Católica de Córdoba (UCC)
- 申请人地址： Av. Rivadavia 1906 piso 3 depto. F Buenos Aires C1033AAJ AR
- 专利权人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet),Universidad Católica de Córdoba (UCC)
- 当前专利权人： Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet),Universidad Católica de Córdoba (UCC)
- 当前专利权人地址： Av. Rivadavia 1906 piso 3 depto. F Buenos Aires C1033AAJ AR
- 代理机构： Torner Lasalle, Elisabet
- 优先权： US119058P 20081202
- 国际公布： WO2010064204 20100610
- 主分类号： A61K35/68
- IPC分类号： A61K35/68 ; A61K39/002 ; C07K14/44 ; C12N15/113 ; C12N1/20 ; C12R1/90
摘要：
Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.
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