发明公开
- 专利标题： NECTIN-4 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS
- 专利标题（中）： 型Nectin-4靶基因用于癌症治疗和诊断
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申请号： EP09831596.3申请日： 2009-08-21
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公开(公告)号： EP2373794A1公开(公告)日： 2011-10-12
- 发明人: NAKAMURA, Yusuke , DAIGO, Yataro , TSUNODA, Takuya , KISHI, Yoshiro , FUJII, Yoshihiro
- 申请人： Oncotherapy Science, Inc.
- 申请人地址： 2-1, Sakado 3-chome Takatsu-ku Kawasaki-shi Kanagawa 213-0012 JP
- 专利权人： Oncotherapy Science, Inc.
- 当前专利权人： Oncotherapy Science, Inc.
- 当前专利权人地址： 2-1, Sakado 3-chome Takatsu-ku Kawasaki-shi Kanagawa 213-0012 JP
- 代理机构： Plougmann & Vingtoft A/S
- 优先权： US201811P 20081212
- 国际公布： WO2010067487 20100617
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K31/713 ; C12Q1/68 ; G01N33/53
摘要：
The present invention features methods for diagnosing cancer or assessing or determining the prognosis of a patient with lung cancer, by detecting the expression level of Nectin-4. The present invention also features double-stranded molecules against the Nectin-4 gene, vectors encoding them, compositions comprising them and methods comprising the step of administering them into a subject, which are useful for treating or preventing cancer. Also, disclosed are methods of identifying candidate compounds for treating and preventing cancer, using the Nectin-4 polypeptide or cells expressing the Nectin-4 gene.
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