发明公开
EP2376480A2 SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES
有权
磺胺ALS BCL-2选择性诱导细胞凋亡的手段治疗癌症和免疫系统疾病的
- 专利标题： SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES
- 专利标题（中）： 磺胺ALS BCL-2选择性诱导细胞凋亡的手段治疗癌症和免疫系统疾病的
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申请号： EP09795606.4申请日： 2009-12-04
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公开(公告)号： EP2376480A2公开(公告)日： 2011-10-19
- 发明人: BRUNCKO, Milan , DING, Hong , DOHERTY, George, A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron, R. , MANTEI, Robert, A. , MCCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D.
- 申请人： Abbott Laboratories
- 申请人地址： 100 Abbott Park Road Abbott Park, Illinois 60064 US
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： 100 Abbott Park Road Abbott Park, Illinois 60064 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US120275P 20081205; US181180P 20090526
- 国际公布： WO2010065865 20100610
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/404 ; A61P35/00
摘要：
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BcI -2 or BcI -xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti -aooptotic Bcl-2 protein.
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