发明公开
EP2376535A1 ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION
有权
抗体-PD-L1抗体在DEREN VERWENDUNG ZUR VERBESSERUNG DER T-ZELLEN-FUNKTION
- 专利标题: ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION
- 专利标题(中): 抗体-PD-L1抗体在DEREN VERWENDUNG ZUR VERBESSERUNG DER T-ZELLEN-FUNKTION
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申请号: EP09764997.4申请日: 2009-12-08
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公开(公告)号: EP2376535A1公开(公告)日: 2011-10-19
- 发明人: IRVING, Bryan , CHEUNG, Jeanne , CHIU, Henry , LEHAR, Sophie, M. , MAECKER, Heather , MARIATHASAN, Sanjeev , WU, Yan
- 申请人: Genentech, Inc. , F.Hoffmann-La Roche AG
- 申请人地址: 1 DNA Way South San Francisco, CA 94080 US
- 专利权人: Genentech, Inc.,F.Hoffmann-La Roche AG
- 当前专利权人: Genentech, Inc.,F.Hoffmann-La Roche AG
- 当前专利权人地址: 1 DNA Way South San Francisco, CA 94080 US
- 代理机构: Brodbeck, Michel
- 优先权: US121092P 20081209
- 国际公布: WO2010077634 20100708
- 主分类号: C07K16/28
- IPC分类号: C07K16/28 ; A61P35/00 ; A61K39/395
摘要:
The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection ( e.g ., acute and chronic) and tumor immunity.
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