发明公开
EP2383262A1 PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
有权
PHENYLPYRIMIDONVERBINDUNGEN，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN，HERSTELLUNGSVERFAHREN UND ANWENDUNGEN DAVON
- 专利标题： PHENYL PYRIMIDONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PREPARATION METHODS AND USES THEREOF
- 专利标题（中）： PHENYLPYRIMIDONVERBINDUNGEN，PHARMAZEUTISCHE ZUSAMMENSETZUNGEN，HERSTELLUNGSVERFAHREN UND ANWENDUNGEN DAVON
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申请号： EP09831388.5申请日： 2009-12-10
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公开(公告)号： EP2383262A1公开(公告)日： 2011-11-02
- 发明人: LIU, Zheng , LI, Jianfeng , YANG, Xiaojun , WANG, Zhen , ZHANG, Jinfeng , ZHU, Yi , TIAN, Guanghui , JIN, Qing , SHEN, Jingkang , ZHU, Weiliang , JIANG, Hualiang , SHEN, Jingshan
- 申请人： Topharman Shanghai Co., Ltd. , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Topharman Shandong Co., Ltd.
- 申请人地址： 1088 Chuansha Road Pudong New District Shanghai 201209 CN
- 专利权人： Topharman Shanghai Co., Ltd.,Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Topharman Shandong Co., Ltd.
- 当前专利权人： Topharman Shanghai Co., Ltd.,Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Topharman Shandong Co., Ltd.
- 当前专利权人地址： 1088 Chuansha Road Pudong New District Shanghai 201209 CN
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： CN200810204368 20081210
- 国际公布： WO2010066111 20100617
- 主分类号： C07D239/36
- IPC分类号： C07D239/36 ; A61K31/505 ; A61P15/10
摘要：
The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof; and to the pharmaceutical composition as well as the preparation method of the said compounds. The said compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like.
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