发明公开
- 专利标题： Method of increasing the function of an AAV vector
- 专利标题（中）： 改性的含这些组合物AAVrh.64衣壳和其用途。
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申请号： EP10184600.4申请日： 2006-04-07
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公开(公告)号： EP2383346A1公开(公告)日： 2011-11-02
- 发明人: Gao, Guangping , Wilson, James M. , Vandenberghe, Luk
- 申请人： The Trustees of the University of Pennsylvania
- 申请人地址： 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104 US
- 专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人： The Trustees of the University of Pennsylvania
- 当前专利权人地址： 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104 US
- 代理机构： Manaton, Ross Timothy
- 优先权： US669083P 20050407; US733497P 20051104
- 主分类号： C12N15/864
- IPC分类号： C12N15/864 ; C12N7/00 ; A61K35/76 ; A61K48/00
摘要：
A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
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