A specimen retrieval apparatus comprises an elongated tubular member defining a lumen extending therethrough and having a proximal end and a distal end; a vacuum assembly coupled to the proximal end of the elongated tubular member and in communication with the lumen extending therethrough, the vacuum assembly configured for operation in at least one of a suction mode and a pressure mode; a suction cone disposed at the distal end of the elongated tubular member, the suction cone defining an aperture at an apex thereof, the aperture in fluid communication with the lumen of the elongated tubular member, the suction cone configured to suction a tissue specimen thereto when the vacuum assembly is operating in the suction mode; and a specimen retrieval bag disposed at a distal end of the elongated tubular member, the bag being inflatable from an un-deployed state to a deployed state when the vacuum assembly is operating in the pressure mode.