发明公开
EP2396038A2 TREATMENT OF BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO BDNF
有权
治疗脑源性神经营养因子（BDNF）的可通过抑制天然反义转录反对BDNF的疾病
- 专利标题： TREATMENT OF BRAIN DERIVED NEUROTROPHIC FACTOR (BDNF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO BDNF
- 专利标题（中）： 治疗脑源性神经营养因子（BDNF）的可通过抑制天然反义转录反对BDNF的疾病
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申请号： EP10741789.1申请日： 2010-02-12
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公开(公告)号： EP2396038A2公开(公告)日： 2011-12-21
- 发明人: COLLARD, Joseph , KHORKOVA SHERMAN, Olga , COITO, Carlos
- 申请人： Opko Curna, LLC
- 申请人地址： 4400 Biscayne Boulevard Miami, FL 33137 US
- 专利权人： Opko Curna, LLC
- 当前专利权人： Opko Curna, LLC
- 当前专利权人地址： 4400 Biscayne Boulevard Miami, FL 33137 US
- 代理机构： Evenson, Jane Harriet
- 优先权： US152132P 20090212
- 国际公布： WO2010093904 20100819
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K38/16 ; A61P25/16 ; A61P25/28 ; A61P25/00
摘要：
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Brain derived neurotrophic factor (BDNF), in particular, by targeting natural antisense polynucleotides of Brain derived neurotrophic factor (BDNF). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of BDNF.
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