发明公开
- 专利标题： NOVEL MICROBIAL SUCCINIC ACID PRODUCERS AND PURIFICATION OF SUCCINIC ACID
- 专利标题（中）： 奥古斯丁·伯恩斯坦先生
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申请号： EP10708150.7申请日： 2010-02-12
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公开(公告)号： EP2396401A1公开(公告)日： 2011-12-21
- 发明人: SCHRÖDER, Hartwig , HAEFNER, Stefan , ABENDROTH, Gregory von , HOLLMANN, Rajan , RADDATZ, Aline , ERNST, Hansgeorg , GURSKI, Hans
- 申请人： BASF SE
- 申请人地址： 67056 Ludwigshafen DE
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： 67056 Ludwigshafen DE
- 优先权： EP09152959 20090216; US245306P 20090924; EP09171250 20090924
- 国际公布： WO2010092155 20100819
- 主分类号： C12N1/32
- IPC分类号： C12N1/32 ; C12P7/46 ; C12R1/01 ; C12P17/10
摘要：
The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.
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