发明公开
EP2398809A1 NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
有权
硬脂酰辅酶AΔ9去饱和酶的新螺环化合物作为抑制剂
- 专利标题： NOVEL SPIRO COMPOUNDS USEFUL AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
- 专利标题（中）： 硬脂酰辅酶AΔ9去饱和酶的新螺环化合物作为抑制剂
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申请号： EP10743365.8申请日： 2010-02-16
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公开(公告)号： EP2398809A1公开(公告)日： 2011-12-28
- 发明人: LACHANCE, Nicolas , LECLERC, Jean-Philippe , LI, Chun, Sing , MORADEI, Oscar, Miguel
- 申请人： Merck Canada Inc.
- 申请人地址： 16711 Trans-Canada Highway Kirland QC H9H 3L1 CA
- 专利权人： Merck Canada Inc.
- 当前专利权人： Merck Canada Inc.
- 当前专利权人地址： 16711 Trans-Canada Highway Kirland QC H9H 3L1 CA
- 代理机构： Jaap, David Robert
- 优先权： US207784P 20090217; US249284P 20091007
- 国际公布： WO2010094120 20100826
- 主分类号： C07D491/107
- IPC分类号： C07D491/107 ; A61K31/438 ; A61P3/00 ; C07D417/14
摘要：
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.
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